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Encapsulation in monodispersed hydrogel microspheres enables fast and sensitive phenotypic analyses using COPAS large particle flow cytometry.
Three dimensional scaffolds provide significant innovative advances in the handling and use of live cells. Scaffolds can be used in a number of ways, such as for the isolation of individual cells to form clonal populations, for establishing partial barrier for cells from their environment, and for creating a matrix allowing the formation of 3D cell cultures. These methods have important implications for the biomedical engineering field and the areas of biomanufacturing and bioprocessing. However, much is left to be learned about 3D-matrix fabrication and use. For example, the chemical composition and engineered functionalities affect the biology of the encapsulated cells. One particular system that has achieved wide usage has been the alginate polymer. Recent experiments by Delgado, et al., demonstrated that a variety of cell types can be enclosed in alginate, maintaining their morphology and function; they proliferate, form cell clusters, and even lay down extracellular matrix components. Furthermore, the cells can be encapsulated in small particles that can then be handled, characterized and analyzed. These features make alginate a widely acceptable material for three dimensional scaffolds of live cells.
About Union Biometrica, Inc.
Union Biometrica designs and markets flow cytometers for objects that are too large / too fragile for traditional cytometers and offer an alternative to manual sorting (under a microscope). These systems sort and dispense objects based on size and fluorescent parameters. Automating this process offers increased speed, sensitivity, quantification, and repeatability of experiments. For more details please visit:
http://www.unionbio.com/documents/QTN019_Alginate_applications.pdf