VAST Publications - VAST D. rerio (zebrafish)

Adaptive Optics in an Oblique Plane Microscope

McFadden et al.
March 22, 2024
bioRxiv 2024.03.21.586191; doi:

Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy

Oprisoreanu et al.
April 26, 2021
Dis Model Mech (2021) 14 (4): dmm047761.

Assessment of Autism Zebrafish Mutant Models Using a High-Throughput Larval Phenotyping Platform

Colón-Rodríguez A, et al.
November 23, 2020
Front. Cell Dev. Biol. 8:586296.; doi: 10.3389/fcell.2020.586296

Morphometric analysis of developing zebrafish embryos allow predicting teratogenicity modes of action in higher vertebrates

Jarque et al.
August 19, 2020
Reproductive Toxicology 96 (2020) 337-348;

Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/ Cas9-based approach

von der Heyde et al.
July 16, 2020
Sci Rep 10, 11831 (2020).

TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci

Davis et al.
July 03, 2020
Human Molecular Genetics, , ddaa120,

Integrative discovery of treatments for high-risk neuroblastoma

Almstedt et al.
January 03, 2020
Nat Commun. 2020 Jan 3;11(1):71. doi: 10.1038/s41467-019-13817-8.

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Morikawa et al.
November 12, 2019
Science Signaling 12 Nov 2019: Vol. 12, Issue 607, eaay4430 DOI: 10.1126/scisignal.aay4430

Comparison of Zebrafish Larvae and hiPSC Cardiomyocytes for Predicting Drug-Induced Cardiotoxicity in Humans

Sylvia Dyballa et al.
October 01, 2019
Toxicological Sciences, Volume 171, Issue 2, October 2019, Pages 283–295,

TAF1, associated with intellectual disability in humans, is essential for embryogenesis and regulates neurodevelopmental processes in zebrafish

Gudmundsson et al.
September 01, 2019
Sci Rep. 2019; 9: 10730. Published online 2019 Jul 24. doi: 10.1038/s41598-019-46632-8

Zebrafish larvae as a model system for systematic characterization of drugs and genes in dyslipidemia and atherosclerosis

Bandaru et al.
June 11, 2019
bioRxiv 502674; doi:

Bi-allelic Variants in DYNC1I2 Cause Syndromic Microcephaly with Intellectual Disability, Cerebral Malformations, and Dysmorphic Facial Features

Ansar et al.
May 09, 2019

An automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos’

Jarque et al.
August 29, 2018
PLOS ONE | August 29, 2018

An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination

Early et al.
July 06, 2018
DOI: 10.7554/eLife.35136 DOI: 10.7554/eLife.35136

Three-dimensional reconstruction and measurements of zebrafish larvae from high-throughput axial-view in vivo imaging

Guo et al.
April 26, 2017; Received 9 Nov 2016; revised 31 Jan 2017; accepted 31 Jan 2017; published 26 Apr 2017

A truncating mutation in CEP55 is the likely cause of MARCH, a novel syndrome affecting neuronal mitosis.

Frosk et al.
March 06, 2017
J Med Genet. 2017 Mar 6. pii: jmedgenet-2016-104296. doi: 10.1136/jmedgenet-2016-104296. [Epub ahead of print]

SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome

Shaw et al.
January 09, 2017
Nature Genetics (2017) doi:10.1038/ng.3743

De Novo Disruption of the Proteasome Regulatory Subunit PSMD12 Causes a Syndromic Neurodevelopmental Disorder

Kury et al.
January 03, 2017

Developing systems for high-throughput screening of infectious diseases using zebrafish

Veneman, Wouter Jurjen
December 05, 2015
Department of Animal Sciences and Health, Institute of Biology, Faculty of Science, Leiden University

Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type.

Mala Isrie 1,2 et al.
October 14, 2015
Am J Hum Genet. 2015 Dec 3;97(6):790-800. doi: 10.1016/j.ajhg.2015.10.014.

1Center for Human Genetics, University Hospitals Leuven, 3000 Leuven, Belgium;  2Laboratory for Genetics of Cognition, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium

Semi-automated detection of goitrogenic compounds using transgenic zebrafish embryos and the VAST BioImager platform

SETAC Europe 25th Annual Meeting
Sergio Jarque¹, Eva Fetter², Marek Pípal¹, Marie Smutná¹, Ludek Blaha¹, Stefan Scholz².
May 03, 2015

1RECETOX, Masaryk University, Faculty of Science, Kamenice 753/5, 625 00, Brno

2Department of Bioanalytical Ecotoxicology, Helmholtz Centre for Environmental Research – UFZ, Permoserstraße 15, 04318 Leipzig, Germany

Establishment and optimization of a high throughput setup to study Staphylococcus epidermidis and Mycobacterium marinum infection as a model for drug discovery.

Veneman WJ¹, Marín-Juez R², de Sonneville J³, Ordas A4, Jong-Raadsen S², Meijer AH4, Spaink HP5.
June 26, 2014

1Institute of Biology, Leiden University; 2ZF-screens BV. 3Life Science Methods BV. 4Institute of Biology, Leiden University. 5Institute of Biology, Leiden University

High-throughput hyperdimensional vertebrate phenotyping

Carlos Pardo-Martin, Amin Allalou, Jaime Medina, Peter M. Eimon, Carolina Wählby Mehmet Fatih Yanik
February 12, 2013
Nature Communications 4, Article number:1467, doi:10.1038/ncomms2475

Presenting VAST BioImager™: A new modular, expandable platform to automate the orientation of 2-7 day old zebrafish larvae for imaging

The Nordic Countries Zebrafish Meeting on the Zebrafish as a model for Development and Disease
Union Biometrica, Geel, Belgium, Union Biometrica, Holliston, MA, USA Yanik lab, MIT, Boston, MA, USA
November 21, 2012

Fully automated cellular-resolution vertebrate screening platform with parallel animal processing

Chang TY, Pardo-Martin C, Allalou A, Wählby C, Yanik MF.
February 01, 2012
Lab Chip. 2012 Feb 21;12(4):711-6. doi: 10.1039/c1lc20849g. Epub 2011 Dec 8.

High-throughput in vivo vertebrate screening.

Pardo-Martin C, Chang TY, Koo BK, Gilleland CL, Wasserman SC, Yanik MF.
August 01, 2010
Nat Methods. 2010 Aug;7(8):634-6. doi: 10.1038/nmeth.1481. Epub 2010 Jul 18.