Applications & Publications
Publications
The Ocular Surface Immune System through the Eyes of Aging
Galletti and de Paiva February 20, 2021 Ocul Surf. Author manuscript; available in PMC 2022 Apr 1.Published in final edited form as: Ocul Surf. 2021 Apr; 20: 139–162. Published online 2021 Feb 20. doi: 10.1016/j.jtos.2021.02.007
View AbstractThe Ocular Surface Immune System through the Eyes of Aging
Since the last century, advances in healthcare, housing, and education have led to an increase in life expectancy. Longevity is accompanied by a higher prevalence of age-related diseases, such as cancer, autoimmunity, diabetes, and infection, and part of this increase in disease incidence relates to the significant changes that aging brings about in the immune system. The eye is not spared by aging either, presenting with age-related disorders of its own, and interestingly, many of these diseases have immune pathophysiology. Being delicate organs that must be exposed to the environment in order to capture light, the eyes are endowed with a mucosal environment that protects them, the so-called ocular surface. As in other mucosal sites, immune responses at the ocular surface need to be swift and potent to eliminate threats but are at the same time tightly controlled to prevent excessive inflammation and bystander damage. This review will detail how aging affects the mucosal immune response of the ocular surface as a whole and how this process relates to the higher incidence of ocular surface disease in the elderly.
Flow Cytometry for "Large Objects" (40-1,000 microns): HTS of bead-based combi-chem libraries, model organisms (C. elegans, Drosophila, zebra fish), Arabidopsis seeds, pollen, etc., #33.
Laboratory Robotics Interest Group (LRIG) New England Meeting,
R. Pulak, B. Wang, J. Thompson, B. Moellers, C. Bogan, T. Mullins, D. Perrault, K. Ver Donck*, J.Geysen* ~ Union Biometrica, Inc. (Holliston, MA; Geel, BE*;)
January 05, 2006
Flow Cytometry for "Large Objects" (40-1,000 microns): HTS of bead-based combi-chem libraries, model organisms (C. elegans, Drosophila, zebra fish), Arabidopsis seeds, pollen, etc., #33.
Drug Discovery & Development, "Characterizing Targets in Model Organisms"
Alan Dove November 01, 2005
Drug Discovery & Development, "Characterizing Targets in Model Organisms"
Go With the Flow: Sorting Cells and Other Small Things
Angelo DePalma, PhD. September 01, 2004 Drug Discovery & Development
Go With the Flow: Sorting Cells and Other Small Things
Flow Cytometry: Cytometers are getting smaller, cheaper, faster, and better
May 05, 2003 The Scientist, Volume 17, Issue 9, 43, May 5, 2003.
Flow Cytometry: Cytometers are getting smaller, cheaper, faster, and better
Novel High-Throughput Screening Technologies Fluorescence, Bioluminescence & Flow Cytometry Aid Drug Discovery
March 15, 2003 Genetic Engineering News Volume 23, Number 6, March 15, 2003, pp. 10-13.
Novel High-Throughput Screening Technologies Fluorescence, Bioluminescence & Flow Cytometry Aid Drug Discovery
The principles of scale space applied to structure and colour in light microscopy
September 01, 2002 Proceedings of the Royal Microscopical Society, 37 (3): 161-166. SEPTEMBER, 2002
The principles of scale space applied to structure and colour in light microscopy
The World of Small Model Organisms Just Got Larger: Companies have identified disease pathways that can be targeted for drug discovery using worms, fruit flies, and zebrafish
March 01, 2002 Drug Discovery & Development Magazine
The World of Small Model Organisms Just Got Larger: Companies have identified disease pathways that can be targeted for drug discovery using worms, fruit flies, and zebrafish
Genetic Analysis of Digestive Physiology Using Fluorescent Phosolipid Reporters
May 18, 2001 Science Magazine Volume 292, Number 5520, Issue of 18 May 2001, pp. 1385-1388.
View AbstractGenetic Analysis of Digestive Physiology Using Fluorescent Phosolipid Reporters
Zebrafish are a valuable model for mammalian lipid metabolism; larvae process lipids similarly through the intestine and hepatobiliary system and respond to drugs that block cholesterol synthesis in humans. After ingestion of fluorescently quenched phospholipids, endogenous lipase activity and rapid transport of cleavage products results in intense gall bladder fluorescence. Genetic screening identifies zebrafish mutants, such as fat free, that show normal digestive organ morphology but severely reduced phospholipid and cholesterol processing. Thus, fluorescent lipids provide a sensitive readout of lipid metabolism and are a powerful tool for identifying genes that mediate vertebrate digestive physiology.
Living the high (throughput) life: HTS looks for rewards from the use of cellular assays
May 01, 2001 Modern Drug Discovery Magazine May 2001, Vol. 4, No. 5, pp 40-42, 44, 47.
Living the high (throughput) life: HTS looks for rewards from the use of cellular assays
Union Biometrica Eschews "Warm-and-Fuzzy" in Medical Research
April 23, 2001 Boston Business Journal p. 4 & p. 20.
Union Biometrica Eschews "Warm-and-Fuzzy" in Medical Research
Drug Discovery Tutorial: Automated Testing and Model Organisms
February 15, 2001 Genetic Engineering News vol. 21,no. 4 p.32 and 61.
Drug Discovery Tutorial: Automated Testing and Model Organisms
No worm's pace here
November 29, 2000 The Boston Globe pp. C8-C9.
No worm's pace here
Animal Models of Disease
Chaoyong Ma Modern Drug Discovery June 2004, Volume 7, Issue 6, pp. 30-36