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FOR IMMEDIATE RELEASE

Pioneer of Drug Screening System Partners with Aventis Pharma; Union Biometrica Backed on Automated Tools for Pharmaceutical Research
Business Editors and Health/Medical Writers
Holliston, MA | Dec. 11, 2000


Union Biometrica Inc., inventor of the only automated system for drug testing in model organisms, announced today a collaboration with pharmaceutical giant Aventis which will provide funding to further Union Biometrica's research and development of its breakthrough technology.

The partnership will focus on use of Union Biometrica's recently developed instrumentation and tools for rapid screening of the nematode, Caenorhabditis elegans. C. elegans was the first complex, multicellular organism for which the DNA sequence of the entire genome was completed. This nematode is a very attractive model for biomedical research and drug R&D because a large percentage of human genes, including many genes associated with human illnesses, also appear in the C. elegans genome. Union Biometrica will co-develop with Aventis biological materials and screening assays.

The collaboration also will provide the opportunity for Aventis Pharma scientists to work with the sophisticated technology at Union Biometrica's Holliston facility. In return, Union Biometrica will place one of its COPAS Technology Platform systems in the Aventis Center for Functional Genomics in Martinsried, Germany, for accelerated analysis of gene function in C. elegans.

The automated COPAS system, already in use by several other prominent pharmaceutical companies in the United States and Europe, enables scientists to screen thousands of drugs on tens of thousands of live animals in days, rather than the year or two such testing has taken with examinations through microscopes.

About Union Biometrica Inc.
Headquartered in Holliston, MA, Union Biometrica Inc. (www.unionbio.com) was founded in 1994 as a creator of customized research systems for drug discoveries in the pharmaceutical and biomedical communities. The company's founders, Peter Hansen and Petra Krauledat, have a combined 50 years of experience in biochemistry and the development of analytical systems.

About Aventis
Aventis (NYSE: AVE) is a world leader in life sciences. Aventis is dedicated to improving life through the discovery and development of innovative products in the fields of prescription drugs, vaccines, therapeutic proteins, crop production and protection, animal health and nutrition. With global corporate headquarters in Strasbourg, France, Aventis was launched in December 1999 through the merger of Hoechst AG of Germany and Rhone-Poulenc SA of France.